An Oklahoma family, driven off their farm by the poverty and hopelessness of the Dust Bowl, joins the westward migration to California, suffering the misfortunes of the homeless in the Great Depression. The Grapes of Wrath has a runtime of 2 hours and 9 minutes and is rated TV-PG.

According to film historian Jeff Berg, the second unit director filmed in New Mexico and other states. Berg says, "All New Mexico shots are long shots, but the ones done around Gallup, Santa Rosa, and Laguna Pueblo may have helped create the glory days of Gallup filmmaking."

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